St. John's Wort is thought to be a safe and effective treatment for mild to moderate depression and SAD.  However, the problem with it (and so many other herbal remedies) being available over the counter, is that people automatically assume that they are perfectly safe to take, no matter what else they are taking. Therefore, they don't discuss potential drug interactions with their doctor or pharmacist before taking it (a NO NO, as I discussed in an earlier blog entry).   The fact is, St. John's Wort is safe, if it is taken by itself. However, studies show that St. John's Wort also boosts the liver enzyme called CYP3A4 which may metabolize a number of drugs before they have a chance to do what they are supposed to do.  This list includes Chemotherapy and HIV drugs, birth control pills and some anti-anxiety medications.  It may also increase the side-effects of other depression medications if they are taken together.  For more information on what drugs St. John's Wort may interfere with, please check here.  Remember, herbal remedies can be safe and effective in a lot of instances, but ALWAYS check with your doctor or pharmacist first.